"目录号: HY-15283
Clopidogrel是口服活性的P2Y12受体阻断剂。
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Suramin sodium salt-Clopidogrel hydrogen sulfate-Ticagrelor-MRS 2578-Prasugrel-AZD1283-N6-(4-Hydroxybenzyl)adenosine-Diquafosol tetrasodium-Denufosol tetrasodium-
生物活性
Description
Clopidogrel is a well-known P2Y12 receptor blocker.IC50 value:Target: P2Y12 receptorClopidogrel (INN) is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi under the trade name Plavix. The drug works by irreversibly inhibiting a receptor called P2Y12, an adenosine diphosphate (ADP) chemoreceptor on platelet cell membranes. Adverse effects include hemorrhage, severe neutropenia, and thrombotic thrombocytopenic purpura (TTP). From Wikipedia
Clinical Trial
University of Maryland-Food and Drug Administration (FDA)-National Cancer Institute (NCI)-National Institute of General Medical Sciences (NIGMS)
Metabolism of Clopidogrel
July 2010
Seoul National University Hospital
Influence of Genotype of Drug Metabolizing Enzyme or Transporter on the Pharmacokinetics/Pharmacodynamics of Clopidogrel-Influence of Aspirin on the Pharmacokinetics/Pharmacodynamics of Clopidogrel
January 2012
Phase 4
AstraZeneca
Bioequivalence, AUC, Cmax, Pharmacokinetics
August 2014
Phase 1
Chinese PLA General Hospital
CLOPIDOGREL, POOR METABOLISM of (Disorder)
October 2014
Phase 2-Phase 3
University of North Carolina, Chapel Hill
Disease Susceptibility
March 2010
Phase 2
Icahn School of Medicine at Mount Sinai-Doris Duke Charitable Foundation
Clopidogrel
January 2012
Phase 2
Khon Kaen University
Pharmacodynamics
August 2013
Phase 1
Dr. Reddy's Laboratories Limited
Healthy
October 2006
Phase 1
University of Pecs
Acute Coronary Syndrome
September 2011
Phase 4
Hospital Central San Luis Potosi, Mexico
Acute Coronary Syndrome
February 2016
Phase 4
Ruhr University of Bochum
Coronary Artery Disease
October 2008
Catharina Ziekenhuis Eindhoven
Coronary Artery Disease
June 2006
Phase 4
The Third Affiliated Hospital of Guangzhou Medical University
Cerebral Infarction-Clopidogrel,Poor Metabolism of (Disorder)
March 2015
Phase 4
Laval University-Sanofi-Bristol-Myers Squibb
Migraine
October 2008
Phase 4
Neil Kleiman, MD-The Methodist Hospital System
Coronary Artery Disease
January 2010
Phase 4
Hospital Universitario Dr. Jose E. Gonzalez
Comparative Bioavailability of Clopidogrel Tablets
May 2008
Phase 1
Ottawa Heart Institute Research Corporation
Acute Coronary Syndrome
December 2013
Phase 4
First Affiliated Hospital Xi'an Jiaotong University
Migraine
October 2016
Phase 4
Dr. Reddy's Laboratories Limited
Fasting
September 2006
Phase 1
University of Sao Paulo-Fundação de Amparo à Pesquisa do Estado de São Paulo
Platelet Aggregation-Adenosine-Coronary Artery Disease-Kidney Dysfunction-Antiplatelet Therapy
July 1, 2017
Phase 2
Dr. Reddy's Laboratories Limited
Healthy
September 2008
Phase 1
Sanofi-Bristol-Myers Squibb
Healthy
March 2009
Phase 1
Dr. Reddy's Laboratories Limited
Fasting
August 2008
Phase 1
Rapid City Regional Hospital, Inc-AstraZeneca
Coronary Artery Disease
December 2012
Phase 4
Samsung Medical Center
Clopidogrel Non-Responsiveness
February 2008
Deutsches Herzzentrum Muenchen
Coronary Artery Disease
April 2008
Phase 4
Ajou University School of Medicine-Dong-A Pharmaceutical
Acute Coronary Syndrome
October 2010
Phase 4
University of Massachusetts, Worcester-Sanofi-Bristol-Myers Squibb
Blood Platelets-Clopidogrel
April 2008
Daiichi Sankyo Inc.
Coronary Artery Disease
November 2010
Phase 4
Daiichi Sankyo Inc.
Drug Interaction
December 2015
Phase 1
Centre Hospitalier Universitaire de Saint Etienne-Groupe de Recherche sur la Thrombose
Brain Ischemia-Ischemic Attack
September 2013
Dong-A University
Acute Coronary Syndrome
September 2012
Phase 3
Medical Center of South Arkansas
Acute ST Segment Elevation Myocardial Infarction-Acute Coronary Syndrome
February 2014
Phase 4
Samsung Medical Center-Yuyu Pharma, Inc.
Carotid Stenosis
June 2014
Phase 3
AHEPA University Hospital-Aristotle University Of Thessaloniki
Diabetes Type 2-Diabetic Nephropathy-Vascular Disease
July 2012
Phase 4
Chinese University of Hong Kong
Gastrointestinal Bleeding
February 2012
Phase 4
Inje University
Healthy
July 2008
Phase 1
Sheffield Teaching Hospitals NHS Foundation Trust-British Heart Foundation-University of Sheffield
Coronary Artery Disease
November 2007
Phase 1
Neil Kleiman, MD-The Methodist Hospital System
Coronary Artery Disease
September 2009
Phase 4
Gennaro Sardella-University of Roma La Sapienza
Acute Coronary Syndrome
October 2011
Phase 3
Chong Kun Dang Pharmaceutical-Inje University
Coronary Artery Disease
December 2010
Phase 1
Dong-A University
Pharmacodynamics
February 2014
Phase 3
University Hospital of Limerick
Myocardial Ischemia-Coronary Artery Disease-Endothelial Dysfunction
July 2015
Phase 4
Emory University
Coronary Artery Disease
January 2008
Phase 4
Ronald Hoffman-Myeloproliferative Disorders-Research Consortium-National Cancer Institute (NCI)-Icahn School of Medicine at Mount Sinai
Polycythemia Vera
June 2009
Phase 2
Seung-Jung Park-CardioVascular Research Foundation, Korea
Coronary Artery Disease
March 2007
Phase 4
Sheba Medical Center
Clopidogrel Non-Responsiveness
March 2005
Phase 3
Seoul National University Hospital
DRUG REACTIONS
January 2013
Phase 4
First Affiliated Hospital of Harbin Medical University
Coronary Artery Disease-Clopidogrel, Poor Metabolism of
February 10, 2017
Phase 2-Phase 3
Daiichi Sankyo Inc.
Coronary Artery Disease
February 2010
Phase 4
